2021
Photothermal and Enhanced Photocatalytic Therapies Conduce to Synergistic Anticancer Phototherapy with Biodegradable Titanium Diselenide Nanosheets
Publication Information
Title:Photothermal and Enhanced Photocatalytic Therapies Conduce to Synergistic Anticancer Phototherapy with Biodegradable Titanium Diselenide Nanosheets
Author(s):Yanhong Duo, Guanghong Luo, Zihuang Li, Zide Chen, Xianming Li, Zhenyou Jiang, Binlu Yu, Hao Huang, Zhengbo Sun, Xue-feng Yu
Journal Name, Year, Volume(Issue):Small, 2021, 17(39): 2103239,Page range:1–19
DOI:10.1002/smll.202103239
Abstract:Nanomaterial-based photothermal and photocatalytic therapies are effective against various types of cancers. However, combining two or more materials is considered necessary to achieve the synergistic anticancer effects of photothermal and photocatalytic therapy, which made the preparation process complicated. Herein, the authors describe simple 2D titanium diselenide (TiSe₂) nanosheets (NSs) that can couple photothermal therapy with photocatalytic therapy. The TiSe₂ NSs show a layered structure and possess high photothermal conversion efficiency (65.58%) and good biocompatibility. Upon near-infrared irradiation, these NSs exhibit good photocatalytic properties with enhanced reactive oxygen species generation and H₂O₂ decomposition. They can also achieve high temperatures, with heat improving their catalytic ability to further amplify oxidative stress and glutathione depletion in cancer cells. Molecular mechanism studies reveal that the synergistic effects can simultaneously lead to apoptosis and necrosis via the HSP90/JAK3/NF-κB/IKB-α/Caspase-3 pathway. Systemic exploration reveals that TiSe₂ NSs have an appreciable degradation rate and accumulate passively in tumor tissue, where they facilitate photothermal and photocatalytic effects without obvious toxicity.
