Dr. Yubo Zhang is a Researcher at the Department of Pharmacology, dedicated to the modernization and translational research of traditional Chinese medicine (TCM).He has published 45 SCI-indexed articles as first or corresponding author , with an h-index of 21, and has filed 22 patent applications (8 granted). He has served as principal investigator on two National-level and five provincial/departmental research projects.   

Modernization and mechanistic elucidation of traditional Chinese medicine (TCM), focusing on bioactive constituents, multi-target pharmacology, and therapeutic potential.

Discovery, isolation, and structural characterization of novel natural products from medicinal herbs.

1.Si-Yu Yang#, Hua-Yan Xie#, Qiang Lin#, Liu-Jin Zhou, Jun-Xi Liu, Ze-Kai Fang, Zi-Ling Tang, Rui-Jie Yuan, Jin-Xuan Su, Si-Jia Li, Wen-Lin Wang, Ming-Yu Pan, Hao Wang,* Xiao-Yong Dai,* Guo-Cai Wang,* and Yu-Bo Zhang*. EM2, a natural product MST1/2 kinase activator, suppresses non-small cell lung cancer via Hippo pathway activation. Advance Science, 2026, 13(1): e10508.

2.Qing Tang#, Kai Zhao#, Hui-Hui Zhu#, Qiang Lin, Hai-Yue Zhao, Wei-Xuan Zheng, Zhong-Nan Wu, Hao Wang*, Guo-Cai Wang*, Yu-Bo Zhang*. Pecanthines A–C, unprecedented dimeric β-carboline alkaloids from the seeds of Peganum harmala. Chinese Chemical Letters, 2025, in press.

3.Ji-Hui Zhang, Hui-Lin Ou, Ting Lu, Si-Yu Yang, Ding Luo, Peng Wu, Yao-Lan Li, Neng-Hua Chen*, Guo-Cai Wang*, Yu-Bo Zhang*. Daphcalycines A–D, four highly rearranged Daphniphyllum alkaloids with cardioprotective activity from Daphniphyllum calycinum. Chinese Chemical Letters, 2026, 37(3): 111314.

4.Zhi-Peng Ling#, Jun-Ping Pan#, Zhong-Fei Zhang#, Gui-Si Chen, Jia-Yuan Geng, Qiang Lin, Tao Zhang, Shu-Qin Cao, Cheng Chen, Jin-Rong Lin, Hong-Yao Yuan, Wei-Long Ding, Fei Xiao, Xin-Ke Xu, Fang-Cheng Li, Guo-Cai Wang*, Yu-Bo Zhang*, Jun-Liang Li*. Small-molecule Molephantin induces apoptosis and mitophagy flux blockage through ROS production in glioblastoma. Cancer Letters 2024, 592: 216927.

5.Qiang Lin#, Hua-Yan Xie#, Qing Tang#, Hai-Shan Zhang, Min-Jing Cheng, Zhao-Chun Zhan, Hong-Xiao Wang, Yao-Lan Li, Hao Wang*, Guo-Cai Wang*, Yu-Bo Zhang*. Garcioblons A-F, polycyclic polyprenylated acylphloroglucinols with diverse rearranged skeletons from Garcinia oblongifolia. Organic Letters, 2025, 27(13), 3273-3278.

Youth Editorial Board Member of Journal of Southern Medical University and a Guest Editor for Frontiers in Pharmacology,

E-mail：ybzhang99（126邮箱）