My scientific research has been focusing on the biology of stem cells and their secretomes. In recent years, my research interests have expanded to exploring the biological functions of exosomes from pluripotent stem cells and their impact and mechanisms on the regenerative potential of degenerated intervertebral disc nucleus cells.    

Main research directions :

I have a strong interest in stem cell biology, particularly in the role of stem cells in the regeneration and repair of degenerated tissue cells. I have been engaged in exploring the impact and mechanism of stem cells and their secretome on the regenerative potential of degenerated nerve cells and degenerated intervertebral disc nucleus tissue.

Representative academic achievements：

2019-2022: Research on the Mechanism of Embryonic Stem Cell Exosomes Reversing the Degeneration of Intervertebral Disc Nucleus Cell Regeneration Capacity. National Natural Science Research Foundation Project. Grant No. 8178198. Principal Investigator.

2018-2020: Research on the Mechanism of Embryonic Stem Cell Exosomes Reversing the Degeneration of Intervertebral Disc Nucleus Cell Regeneration Capacity. Guangdong Provincial Medical Research Foundation Project. Grant No. A2018545. Principal Investigator.

2019-2023: Research on the Construction of Polymer/Liquid Crystal Cell Model and Its Surface Elasticity-Induced Stem Cell Differentiation Behavior. Funding: 600,000 yuan. National Natural Science Foundation of China. No. 31170911. First Participant, responsible for the research on the induced differentiation behavior of cells.

Major Works:

Xian T, Liu Y, Ye Y, Peng B, Huang J, Liang L, Zhang J, Wu H, Lin Z. Human salivary histatin 1 regulating IP3R1/GRP75/VDAC1 mediated mitochondrial-associated endoplasmic reticulum membranes (MAMs) inhibits cell senescence for diabetic wound repair. Free Radic Biol Med. 2024 Nov 20;225:164-180（co-corresponding author）

Yu Y, Li W, Xian T, Tu M, Wu H, Zhang J. Human Embryonic Stem-Cell-Derived Exosomes Repress NLRP3 Inflammasome to Alleviate Pyroptosis in Nucleus Pulposus Cells by Transmitting miR-302c. Int J Mol Sci. 2023 Apr 21;24(8):7664. JCR 1（corresponding author）

Hao Wu, Xiaoli Zeng, Yupan Shang,Lek Hang Cheang, Jiaqing Zhang.Effect of Conditioned Medium from Human UmbilicalCord-Derived Mesenchymal Stromal Cells on Rejuvenationof Nucleus Pulposus Derived stem/ProgenitorCells from Degenerated Intervertebral Disc. International Journal of Stem Cells 2020（co-corresponding author）

Main academic positions:     Member of the Chinese Biochemistry Society

E-mail：zhangjiaqing@jnu.edu.cn