Duomeng Yang

Professor

Department of Pathophysiology

Dr. Yang’s research is focused on innate immunity, sepsis pathogenesis and antiviral innate immune response. Specifically, he attempts to understand the regulation of caspase-4 noncanonical inflammasome and the role of RNA modification in sepsis pathogenesis.

Main research directions :

The role of RNA modification in innate immunity

Sepsis pathogenesis and target identification

Innate immune response in inflammatory diseases

Regulation of noncanonical inflammasome and pyroptosis

Representative academic achievements：

Main findings: The critical roles of UBXNs family in innate immunity, the unanchored polyUb chains regulation of noncanonicalt inflammasome, viruses hijack GLUT4 to control RIG-I like receptor signaling in antiviral innate immune response.

Grant: National Natural Science Foundation of China (2026), Guangdong Natural Science Foundation (2026)

Publications:

1. Duomeng Yang* et al. Unanchored ubiquitin chains promote the non-canonical inflammasome via UBXN1. bioRxiv. 2025, 2nd Revision.

2. Andrew G. Harrison, Duomeng Yang* et al. UBXN9 governs GLUT4-mediated spatial confinement of RIG-I-like receptors and signaling. Nature Immunology. 2024 (IF:27.6).

3. Duomeng Yang* et al. UBR5 promotes antiviral immunity by disengaging the transcriptional brake on RIG-I like receptors. Nature Communications. 2024 (IF:15.7).

4. Duomeng Yang et al. Differential roles of RIG-I like receptors in SARS-CoV-2 infection. Military Medical Research. 2021 (IF:22.9).

5. Duomeng Yang et al. Intrinsic cardiac adrenergic cells contribute to LPS-induced myocardial dysfunction. Communications Biology. 2022 (IF:5.1).

Main academic positions: Member of Chinese Society for Microbiology, Microbiome and Toxin Subcommittee

E-mail：dmyang@jnu.edu.cn