I focus on γδ T-cell tumor immunity and tumor microenvironment regulation, with particular interest in the molecular basis of γδ T-cell functional plasticity and related intervention strategies. My group studies the metabolic, epigenetic, and functional regulation of γδ T cells in the tumor microenvironment, especially how this environment drives their dysfunction and how metabolic or epigenetic interventions can restore their antitumor activity. I have published 14 SCI papers on γδ T cells as first or corresponding author (including co-first/co-corresponding author) in journals such as Signal Transduction and Targeted Therapy, British Journal of Cancer, Clinical and Translational Medicine, Biomaterials, Cellular & Molecular Immunology, Journal for ImmunoTherapy of Cancer, and iScience.

Main research directions:

Antitumor immunity and translational medicine;

Immunometabolic regulation.

Representative academic achievements：

Published papers:

1、Remodeling Hypoxic TNBC Microenvironment Restores Antitumor Efficacy of Vγ9Vδ2 T Cell Therapy. British Journal of Cancer, May 28 2025, 133, 365-380.

2、Hyperglycemic Milieu Impairs Vγ9Vδ2 T Cell Functions in Tuberculosis Patients and Prolongs M.tb Negative Conversion Time. iScience, 2025, 28(1), 111692

3、γδ T cells: origin and fate, subsets, diseases and immunotherapy. Signal Transduction and Targeted Therapy, 2023.11.22, 8: 434

4、Hepatocellular Carcinoma-Infiltrating γδ T Cells are Functionally Defected and Allogenic Vδ2+ γδ T Cell Can be a Promising Complement. Clinical and Translational Medicine, 2022.4, 12: e800.

5、Selenium nanoparticles as new strategy to potentiate γδ T cell anti-tumor cytotoxicity through upregulation of tubulin-α acetylation. Biomaterials, 2019, 222, 119397.

Funding support:

1. Guangdong Provincial General Program (2024), PI, 2025–2027, ongoing

2. NSFC Youth Project (No. 82002787), PI, 2021–2023, completed

3. China Postdoctoral Science Foundation (No. 2017M62898), PI, 2018–2020, completed

Main academic positions: Associate professor, undergraduate and graduate students’ mentor

E-mail：yihu2020@jnu.edu.cn