Xiaoyong Dai, lecturer, master supervisor, department of physiology. The doctor graduated from Tsinghua University. Relevant achievements have been published in 47 SCI papers and 35 patents, with an h-index of 17. Has presided over 3 provincial and ministerial projects, and has been awarded the title of "Outstanding Young Talent" in Neijiang City and "Most Beautiful Science and Technology Worker" in Sanya City.       

Main research directions:

Focus on tumor organoids and tumor drug resistance study. Rich experience in the development of target protein degradation molecules and peptide drugs.

Representative academic achievements：

[1] Hengyuan Gao#, Junqing Lin#, Xiaobing Chen#, ... Junchang Zhang*, Nan Xu*, Xiaoyong Dai*. Microfluidic-based patient-derived organoids recapitulate thyroid cancer heterogeneity and reveal NF-κB-driven maturation for precision therapy. Journal of Translational Medicine. 2026 Feb 27.

[2] Albert Yu#, Yibo Hou#, Kaibin Huang#, ... Tian Meng*, Bing Guo*, Yubo Zhang*, Xiaoyong Dai*. Anti-CD47 antibody-decorated and Cisplatin-containing mesoporous silica nanoparticles for targeted chemoimmunotherapy of colorectal cancer in a patient-derived organoids xenograft model. Interdisciplinary Medicine. 2026 Jan;4(1):e70075.

[3] Yibo Hou#, Zixian Wang#, Wenlin Wang#, ...Yubo Zhang*, Xiaoyong Dai*, Shaohua Ma*. AI-identified CD133-targeting natural compounds demonstrate differential anti-tumor effects and mechanisms in pan-cancer models. EMBO Molecular Medicine. 2025 Nov;17(11):2932-2965.

[4] Jing Li#, Xi Shen#, Chunhui Sun#, ... Lan Ma*, Yubo Zhang*, Xiaoyong Dai*. Isogarcinol inhibits nasopharyngeal carcinoma growth through mitochondria-mediated autophagic cell death. Phytomedicine. 2024 Jul 25:130:155745.

[5] Chunyan Feng, ... Xiaoyong Dai*, Laiqiang Huang*. A novel PDPN antagonist peptide CY12-RP2 inhibits melanoma growth via Wnt/β-catenin and modulates the immune cells. Journal of Experimental & Clinical Cancer Research. 2024 Jan 2;43(1):9.

[6] Kun Wang, ...Shaohua Ma*, Laiqiang Huang*, Xiaoyong Dai*. Nano-LYTACs for Degradation of Membrane Proteins and Inhibition of CD24/Siglec-10 Signaling Pathway. Advanced Science. 2023 Mar 3:e2300288.

Main academic positions:

Served as a young editorial board member of Organ Medicine and iLiver SCI journal, and a reviewer for 20 SCI journals including Advanced Science.

E-mail：daixy18@jnu.edu.cn